•
1 4

The Wellness Abode

Ignite+

$99.99 USD
$99.99 USD
Sale Sold out
  • Ingredients
  • Ingredients

    •  

    Ignite+ is an exclusive breakthrough formula combining the leading ingredients available to increase metabolism, improve insulin signaling, body composition, reduce uptake of glucose into our bodies, and so much more. One of the best ways to prevent insulin resistance is to help remove excess glucose from our blood. We are the first to pair these several effective glucose disposal agents together to target several vital pathways that regulate metabolic efficiency.

    Ignite+ is an advanced metabolic optimization formula whose ingredients have been shown to support:

    • Reduction of adiposity and visceral fat*
    • Increase thermogenesis by raising the metabolic rate and calorie burning*
    • Browning of white adipose tissue*
    • Diet-induced weight gain*
    • Increase fatty acid oxidation*
    • Ramp up ketone levels*
    • Improves glucose tolerance and glucose control*
    • AMPK activation*
    • Leptin and ghrelin levels*
    • Regulation of a healthy metabolism and mitochondrial health*

    WHAT MAKES IGNITE+ SO IMPACTFUL?

    First, we have included InnoSlim®, a proprietary blend of purified, fractionated extracts of Panax notoginseng and Astragalus root produced by a pharmaceutical-grade extraction technology which delivers astragalosides and ginsenosides Rg1 and Rb1. Research has shown it supports the production of adiponectin, a protein hormone that helps modulate metabolic processes such as glucose regulation and fatty acid metabolism. InnoSlim® reduces glucose absorption in the intestine by 42%. This means that only 58% of the glucose you eat will be absorbed in your intestine. In addition, InnoSlim® also increases glucose absorption in muscle and fat cells by 50% and 68% by upregulating GLUT4 transporters, which takes glucose from our blood and transfers it into the muscle tissue. InnoSlim® has also been shown to support appetite control, AMPK activation, insulin resistance, triglycerides and sdLDL in cell, animal and human studies. 

    One other mechanism Ignite targets to improve our metabolic health and weight is to increase the energy expenditure of our bodies. Ignite delivers several ingredients in the formula which help our bodies do this process. Each of these has unique mechanisms of action but combine to make massive differences in the energy we use and how we process glucose in our bloodstream.

      • MitoBurn® (L-BAIBA): Mitoburn® is an exercise mimetic, which mimics exercise’s effect on our tissues. This signals the body to help reduce fatty acids in our system, which are another energy source other than glucose. It can also help produce ketones which reduce appetite and improve energy output. It has also been shown to: Assist in the browning of white fat, activating AMPK, increasing metabolic rate, supporting leptin levels, and insulin resistance.
      • GlucoVantage® Dihydroberberine: Dihydroberberine is a new version of traditional berberine that is up to 5x more bioavailable/absorbable and 2x longer lasting (8 hours vs. 4 hours). In one study, this led to 25.9% reduced blood glucose levels compared to the start of the trial in many patients. Dihydroberberine can also help with advanced glycation end products correlated with aging while supporting blood glucose disposal and improving insulin sensitivity and body composition.
    • DNF-10 satiety peptide complex is obtained from a screening of small molecular weight peptides (<10 kDa) after proteolysis of Saccharomyces cerevisiae, a non-pathogenic yeast. The peptides from DNF-10 lower the hypothalamic expression of neuropeptide Y and downregulate ghrelin, thereby reducing the physiological hunger cues confirmed in multiple published studies.
    • CalorieBurn GP® Grains of Paradise seed extract (6-Paradol 12.5%): CalorieBurn® contains bioactive compounds 6-paradol, 6-shogaol, 6-gingerol, and 6- gingerdione. These have been shown to effectively trigger highly thermogenic Brown Adipose Tissue (BAT) when taken in a precise ratio to one another, resulting in a 5X increase in calories burned over 2 hours compared to placebo. On average, burned 97 kcal more calories daily and lost more visceral fat. In another study, 40mg results in a 400% increase in metabolic rate within 30 minutes. Administration of this also reverses the unbalanced gut microbiota composition induced by a high-fat diet with a decrease in Firmicutes / Bacteroidetes ratio and increase in general Bifidobacterium and Akkermansia.
    • Factor21® (Bitter Melon Extract): Factor21® is a natural regulator of a hormone growth factor called Fibroblast Growth Factor 21 (FGF21) and is an AMPK activator. FGF21 is a potent longevity factor coordinating interactions between energy metabolism and stress responses. Recent studies have revealed that supporting FGF21 can alleviate many age-related metabolic disorders. Factor21® is also an exercise mimetic that has many actions, including improved insulin secretion to drive glucose out of the bloodstream and inhibit fat cell growth.
    • Actiponin® (gynostemma pentaphyllum extract): Actiponin® is a patented, clinically backed, natural fat loss ingredient derived from gynostemma pentaphyllum. The patented technology featured in Actiponin® makes it 10 times more potent than traditional gynostemma pentaphyllum extracts. The fundamental mechanism of Actiponin® is the activation of 5′ AMP-activated protein kinase (AMPK) which is typically activated by exercise and plays a crucial role in metabolic health by regulating fat-burning along with energy production.During 12 weeks of Actiponin® supplementation, total abdominal fat area, body weight, body fat mass, percent body fat, and BMI were significantly decreased. In this same study, waist circumference decreased on average 2.90 cm (1.1 inches) over 3 months.

    Another recent study showed that 88% of Americans were metabolically unhealthy. Metabolic resistance is a concern for everyone as they try to improve their physical appearance and overall health. Ignite is a unique combination of clinically verified ingredients built to help optimize metabolic health and weight control. Together, these ingredients synergize to reduce the factors which lead to weight gain and insulin sensitivity to create the best metabolic control formulation on the market.

     

    REFERENCES:

    General:

    • Araújo, Joana et al. “Prevalence of Optimal Metabolic Health in American Adults: National Health and Nutrition Examination Survey 2009-2016.” Metabolic syndrome and related disorders vol. 17,1 (2019): 46-52. doi:10.1089/met.2018.0105

    CalorieBurn:

    • Sugita J, Yoneshiro T, Hatano T, et al. Grains of paradise (Aframomum melegueta) extract activates brown adipose tissue and increases whole-body energy expenditure in men. Br J Nutr. 2013 Aug;110(4):733-8. doi: 10.1017/S0007114512005715.]
    • Hattori, H., Moriyama, A., Ohno, T., Shibata, T., Iwahashi, H., & Mitsunaga, T. (2022). Molecular networking-based lipid profiling and multi-omics approaches reveal new contributions of functional vanilloids to gut microbiota and lipometabolism changes. Food chemistry. Molecular sciences, 5, 100123. https://doi.org/10.1016/j.fochms.2022.100123

    MitroBurn:

    • Roberts LD, Boström P, O&#39;Sullivan JF, et al. b-Aminoisobutyric acid induces browning of white fat and hepatic b-oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metab. 2014 Jan 7;19(1):96-108. doi: 10.1016/j.cmet.2013.12.003.
    • Tanianskii DA, Jarzebska N, Birkenfeld AL, O&#39;Sullivan JF, Rodionov RN. Beta-Aminoisobutyric Acid as a Novel Regulator of Carbohydrate and Lipid Metabolism. Nutrients. 2019 Feb 28;11(3):524. doi: 10.3390/nu11030524. PMID: 30823446; PMCID: PMC6470580.
    • Kitase, Yukiko et al. “β-aminoisobutyric Acid, l-BAIBA, Is a Muscle-Derived Osteocyte Survival Factor.” Cell reports vol. 22,6 (2018): 1531-1544. doi:10.1016/j.celrep.2018.01.041

    GlucoVantage:

    • Mohammad M, Al-masri IM, Issa A, Khdair A, Bustanji Y. Inhibition of pancreatic lipase by berberine and dihydroberberine: an
    • investigation by docking simulation and experimental validation. Med Chem Res. 2013;22:2273-8. doi: 10.1007/s00044-012-0221-9.
    • Ilyas, Zahra et al. “The effect of Berberine on weight loss in order to prevent obesity: A systematic review.” Biomedicine &amp; pharmacotherapy = Biomedecine &amp; pharmacotherapie vol. 127 (2020): 110137. doi:10.1016/j.biopha.2020.110137
    • Xu, Xinmei et al. “Therapeutic effect of berberine on metabolic diseases: Both pharmacological data and clinical evidence.” Biomedicine &amp; pharmacotherapy = Biomedecine &amp; pharmacotherapie vol. 133 (2021): 110984.doi:10.1016/j.biopha.2020.110984

    DNF-10:

    • Costa MS, Toscano LT, Toscano LLT, Luna VR, Torres RA, Silva JA, Silva AS. Ergogenic potential of foods for performance and recovery: a new alternative in sports supplementation? A systematic review. Crit Rev Food Sci Nutr. 2022;62(6):1480-1501. doi: 10.1080/10408398.2020.1844137. Epub 2020 Nov 23. PMID: 33226268.
    • Jung EY, Kang DH, Suh HJ, Chang UJ. Effects of yeast hydrolysate on neuropeptide Y (NPY) and tryptophan hydroxylase (TPH) immunoreactivity in rats. Phytother Res. 2009 May;23(5):619-23. doi: 10.1002/ptr.2668. PMID: 19107837.
    • Jung EY, Cho MK, Hong YH, Kim JH, Park Y, Chang UJ, Suh HJ. Yeast hydrolysate can reduce body weight and abdominal fat accumulation in obese adults. Nutrition. 2014 Jan;30(1):25-32. doi: 10.1016/j.nut.2013.02.009. PMID: 24290594.
    • Jung EY, Lee JW, Hong YH, Chang UJ, Suh HJ. Low Dose Yeast Hydrolysate in Treatment of Obesity and Weight Loss. Prev Nutr Food Sci. 2017 Mar;22(1):45-49. doi: 10.3746/pnf.2017.22.1.45. Epub 2017 Mar 31. PMID: 28401087; PMCID: PMC5383141.

    Actiponin:

    • Park, Soo-Hyun et al. “Antiobesity effect of Gynostemma pentaphyllum extract (actiponin): a randomized, double-blind, placebo- controlled trial.” Obesity (Silver Spring, Md.) vol. 22,1 (2014): 63-71. doi:10.1002/oby.20539

    Innoslim:

    • Shen YC, Huang SC, Lin CP, et al. Anti-hyperglycemic and anti-hyperlipidemic activities of Radix Astragali and Panax notoginseng extract in human participants: A randomized, double-blind, crossover clinical trial. J Biochem Biotech 2022;5(3):111
    • Wang, Chun-Wen et al. “An Essential Role of cAMP Response Element Binding Protein in Ginsenoside Rg1-Mediated Inhibition of Na+/Glucose Cotransporter 1 Gene Expression.” Molecular pharmacology vol. 88,6 (2015): 1072-83. doi:10.1124/mol.114.097352
    • Huang, Yu-Chuan et al. “Effect and mechanism of ginsenosides CK and Rg1 on stimulation of glucose uptake in 3T3-L1 adipocytes.” Journal of agricultural and food chemistry vol. 58,10 (2010): 6039-47. doi:10.1021/jf9034755
    • Kim, Sung Jip et al. “Ginsenoside Rg1 suppresses hepatic glucose production via AMP-activated protein kinase in HepG2 cells.” Biological &amp; pharmaceutical bulletin vol. 33,2 (2010): 325-8. doi:10.1248/bpb.33.325

    Factor21:

    • Alam MA, Uddin R, Subhan N, Rahman MM, Jain P, Reza HM. Beneficial role of bitter melon supplementation in obesity and related complications in metabolic syndrome. J Lipids. 2015;2015:496169. doi: 10.1155/2015/496169. Epub 2015 Jan 12. PMID: 25650336; PMCID: PMC4306384.
    • Yu, Yongmei et al. “Bitter melon extract attenuating hepatic steatosis may be mediated by FGF21 and AMPK/Sirt1 signaling in mice.” Scientific reports vol. 3 3142. 5 Nov. 2013, doi:10.1038/srep03142
    • Kaess, Bernhard M et al. “FGF21 signalling pathway and metabolic traits - genetic association analysis.” European journal of human genetics : EJHG vol. 18,12 (2010): 1344-8. doi:10.1038/ejhg.2010.130
    • Salminen, Antero et al. “Regulation of longevity by FGF21: Interaction between energy metabolism and stress responses.” Ageing research reviews vol. 37 (2017): 79-93. doi:10.1016/j.arr.2017.05.004